Steric considerations regarding the biodegradation of cholesterol to pregnenolone.-exclusion of (22)-22-hydroxycholesterol and 22-ketocholesterol as intermediates
References (11)
- et al.
Steroids
(1976) - et al.
Biochem. Biophys. Res. Commun
(1974) Diss. ETH
(1975)- et al.
Biochim. Biophys. Acta
(1971) J. Biol. Chem
(1975)
There are more references available in the full text version of this article.
Cited by (21)
Analysis of bioactive oxysterols in newborn mouse brain by LC/MS
2012, Journal of Lipid ResearchCitation Excerpt :22-Oxocholesterol has not previously been reported to be present in brain tissue, nor do we find it in the young female adult brain. However, there is a considerable volume of older literature debating its involvement in the side-chain shortening of cholesterol to pregnenolone (48, 49). The dominant peak in the RIC of m/z 532.3898 is at 7.42 min in Fig. 3A and 16.25 min in Fig. 3B (0.188 ± 0.046 ng/mg) and is not easy to assign.
C-C bond cleavage reactions catalyzed by cytochrome P450 enzymes
2023, Medicinal Chemistry ResearchSubstrate oxidation by cytochrome P450 enzymes
2015, Cytochrome P450: Structure, Mechanism, and Biochemistry, Fourth Edition
Copyright © 1980 Published by Elsevier Inc.