Biochemical and Biophysical Research Communications
Volume 177, Issue 3, 28 June 1991, Pages 1161-1164
Genetic defect of bilirubin UDP-glucuronosyltransferase in the hyperbilirubinemic Gunn rat
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2019, Molecular Therapy Methods and Clinical DevelopmentCitation Excerpt :We next compared the transduction efficiency of (sc)AAV8-hUGT1A1 versus (ss)AAV8-hUGT1A1 in vitro in human hepatoma cells,19 which resulted in a similar expression of the hUGT1A1 transgene (Figure 2A). Next, in vivo comparison of the vectors was performed in a well-established model of CN syndrome, the Gunn rat.24–26 This model presents blood levels of bilirubin comparable to those observed in patients with mild symptoms and no evident signs of brain toxicity (6–12 ± mg/dL). (
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