Elsevier

Biochemical Pharmacology

Volume 18, Issue 7, July 1969, Pages 1749-1762
Biochemical Pharmacology

Inhibition of ethanol metabolism in vivo by administration of pyrazole

https://doi.org/10.1016/0006-2952(69)90164-6Get rights and content

Abstract

In experiments in rats, the in vivo effect of pyrazole on ethanol metabolism was studied. Pyrazole acts as a competitive ADH inhibitor. Ethanol at a dose of 32.6 m-mole/kg was administered. Blood samples were withdrawn at regular intervals, and ethanol analyzed by the automated ADH method and by gas chromatography. Pyrazole in doses of 0.07–8.82 m-mole/kg inhibited the elimination of ethanol by 20 to 90 per cent compared to the control experiments. In the control experiments, ethanol was eliminated in 4 hr, but, after a dose of 8.82 m-mole/kg pyrazole, elimination time was prolonged to between 35 and 50 hr. Inhibition of ethanol metabolism was confirmed by studies with 14C-1-ethanol, which showed a decrease in the excretion rate after pyrazole, with a subsequent decrease in the excretion of 14CO2. The specificity of the inhibitor is discussed.

References (17)

  • H. Theorell et al.

    Biochem. Z.

    (1963)
  • U. Rydberg et al.

    Comm. Dept. Alc. Res., Kwolinska Institutet

    (1964)
  • U. Rydberg et al.

    Comm. Dept. Alc. Res.

    (1964)
  • L. Goldberg et al.

    Comm. Dept. Alc. Res.

    (1964)
  • L. Goldberg et al.

    Comm. Dept. Alc. Res.

    (1964)
  • U. Rydberg

    Comm. Dept. Alc. Res.

    (1964)
  • H. Theorell

    Experientia

    (1965)
  • H. Theorell

    20 års medicinsk forskning

There are more references available in the full text version of this article.

Cited by (0)

View full text