Elsevier

Biochemical Pharmacology

Volume 19, Issue 1, January 1970, Pages 143-150
Biochemical Pharmacology

Properties and reactions of salicyl-coenzyme A

https://doi.org/10.1016/0006-2952(70)90335-7Get rights and content

Abstract

Salicyl-coenzyme A (salicyl-CoA) has been prepared by organic synthesis, and its properties compared to those of benzoyl-CoA. Salicyl-CoA reacts with glycine acyl transferase prepared from both beef and human liver to form salicyluric acid. For both enzymes the rate with salicyl-CoA is approximately 50 per cent of the rate with benzoyl-CoA. In addition, there is a small non-enzymatic acylation of glycine by salicyl-CoA.

References (27)

  • R.K. Kielley et al.

    J. biol. Chem.

    (1950)
  • H. Chantrenne

    J. biol. Chem.

    (1951)
  • D. Schachter et al.

    J. biol. Chem.

    (1953)
  • D. Schachter et al.

    J. biol. Chem.

    (1954)
  • H.R. Mahler et al.

    J. biol. Chem.

    (1953)
  • G. Levy

    J. Pharmac. Sci.

    (1965)
  • E.R. Stadtman
  • P. Goldman

    J. biol. Chem.

    (1965)
  • D. Schachter et al.

    J. biol. Chem.

    (1954)
  • A.J. Quick

    J. biol. Chem.

    (1933)
  • A.J. Quick

    J. biol. Chem.

    (1931)
  • K. Meyer et al.

    Science, N.Y.

    (1948)
  • J. Reid et al.

    Br. med. J.

    (1951)
  • Cited by (25)

    View all citing articles on Scopus

    Postdoctoral Fellow of the U.S. Public Health Service.

    View full text