Elsevier

Biochemical Pharmacology

Volume 24, Issue 2, 15 January 1975, Pages 249-251
Biochemical Pharmacology

Hepatic blood flow and enzyme induction in the rat

https://doi.org/10.1016/0006-2952(75)90284-1Get rights and content

Abstract

Hepatic blood flow and hepatic BSP extraction were estimated in 11 rats injected with phenobarbital for four days and in 10 controls. Hepatic blood flow was not significantly different in phenobarbital-treated rats (8.42 ± 2.43 ml/min per 100g body wt or 1.71 ± 0.42 ml/min per g liver, mean ± 1 S.D.) and in untreated rats (6.64 ± 2.76 ml/min per 100 g body wt or 2.04 ± 0.94 ml/min per g liver). In contrast, BSP extraction was significantly higher in phenobarbital-treated rats (0.83 ± 0.09) than in controls (0.69 ± 0.16; P < 0.05). These results suggest that the increase in BSP clearance observed in phenobarbital-treated rats results from increased hepatic BSP extraction and not from increased hepatic blood flow.

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Present address: Centre Hospitalier et Universitaire, Rouen, France.

Present address: Medizinische Universitätsklinik, Hamburg, German Federal Republic.

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