The role of glutathione conjugation in the mutagenicity of 1,2-dibromoethane
References (24)
- et al.
Biochem. Pharmac.
(1970) Biochem. Pharmac.
(1970)- et al.
Chem. Biol. Interact.
(1978) - et al.
Biochem Pharmac.
(1979) - et al.
J. biol. Chem.
(1964) - et al.
J. biol. Chem.
(1951) - et al.
Biochem. Pharmac.
(1978) - et al.
Mut. Res.
(1975) - et al.
Gastroenterology
(1979) - et al.
Chem-Biol. Interact.
(1977)
Mut. Res.
(1976)
Cited by (156)
Glutathione Transferases
2018, Comprehensive Toxicology: Third EditionGlutathione Transferases
2010, Comprehensive Toxicology, Second EditionAlkyltransferase-mediated toxicity of bis-electrophiles in mammalian cells
2010, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisActivation of alkyl halides by glutathione transferases
2005, Methods in EnzymologyCitation Excerpt :Assays for these reactions involve measurement of glyoxylic acid (or the 2‐carbonyl carboxylic acid corresponding to the substrate, e.g., pyruvic acid from 2,2‐dichloropropionic acid) using HPLC methods (e.g., hydrazones) or GC‐MS (Tong et al., 1998). Most of the early work demonstrating the activation of vic‐dihaloethanes was done with cytosolic fractions or crude preparations of GSTs (Ozawa and Guengerich, 1983; Rannug et al., 1978; van Bladeren et al., 1980). These studies established the role of enzymatic GSH conjugation in DNA binding and genotoxicity (Koga et al., 1986).
Characterization of a Mutagenic DNA Adduct Formed from 1,2-Dibromoethane by O<sup>6</sup>-Alkylguanine-DNA Alkyltransferase
2004, Journal of Biological Chemistry
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