Elsevier

Biochemical Pharmacology

Volume 31, Issue 18, 15 September 1982, Pages 2949-2954
Biochemical Pharmacology

Sulfation of minoxidil by liver sulfotransferase

https://doi.org/10.1016/0006-2952(82)90268-4Get rights and content

Abstract

The 100,000 g supernatant fraction of rat liver homogenate contains a sulfotransferase activity which catalyzes the sulfation of minoxidil. Synthetic minoxidil N-O sulfate and the enzyme synthesized product had identical Chromatographie characteristics on high pressure liquid chromatography. Minoxidil sulfate, which yields minoxidil when treated with sulfatase, was slowly hydrolyzed in water. Several N-oxides of other heterocycles, including several other pyrimidines, triazines and imidazoles, were also substrates for this sulfotransferase.

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