Elsevier

Biochemical Pharmacology

Volume 35, Issue 15, 1 August 1986, Pages 2455-2458
Biochemical Pharmacology

Rapid communication
Identification of S-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: A possible explanation for its nephrocarcinogenicity in male rats

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  • Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity

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    Citation Excerpt :

    Although FMOs and some CYPs share substrates and catalyze the same overall reactions, FMOs have some distinctive substrates, including cysteine S-conjugates of various haloalkenes and haloalkanes. Because of the reactive nature of the various intermediates from this pathway, only NAcDCVC has been recovered in urine of both experimental animals [62,118] and humans [62,63] exposed to TCE or DCVC. Of the two possible bioactivation pathways for DCVC, the CCBL and FMO reactions, the former has received the most attention and is thought to account for most of the bioactivation activity for DCVC [7].

  • Halogenated Hydrocarbons

    2010, Comprehensive Toxicology, Second Edition
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