Kupffer cell factor mediated depression of hepatic parenchymal cell cytochrome P-450
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Cited by (72)
Cytochrome P450 4F subfamily: At the crossroads of eicosanoid and drug metabolism
2006, Pharmacology and TherapeuticsChapter 4 Mechanisms of immunotoxic effects
2004, Immunotoxicology of Drugs and Chemicals: an Experimental and Clinical ApproachExpression of cytochromes P450 4F4 and 4F5 in infection and injury models of inflammation
2003, Biochimica et Biophysica Acta - General SubjectsAlteration of drug biotransformation and elimination during infection and inflammation
2001, Pharmacology and TherapeuticsCitation Excerpt :The loss of drug biotransformation has been studied in a number of different animal models of inflammation, and has been reviewed extensively by Morgan (1997). When particulate matter is phagocytosed, the resultant activation of Kupffer cells leads to a down-regulation of a number of CYP isoforms (Peterson & Renton, 1984, 1986). Agents such as trypan blue dye, zymosan, dextran sulphate, and latex beads have been assumed to lower CYP by activating an inflammatory response within the liver macrophages (Morgan, 1997).
Kupffer cell-mediated differential down-regulation of cytochrome P450 metabolism in rat hepatocytes
1999, European Journal of Pharmacology
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