Inhibition of rat liver microsomal cytochrome P-450 steroid hydroxylase reactions by imidazole antimycotic agents☆
References (24)
- et al.
J. biol. Chem.
(1968) - et al.
Chem. Biol. Interact.
(1978) - et al.
J. biol. Chem.
(1983) - et al.
J. biol. Chem.
(1983) - et al.
J. biol. Chem.
(1953) - et al.
J. biol. Chem.
(1949) - et al.
J. biol. Chem.
(1964) - et al.
J. biol. Chem.
(1963) - et al.
J. biol. Chem.
(1973) - et al.
J. biol. Chem.
(1984)
Pharmac. Ther.
J. Pharmac. exp. Ther.
Cited by (96)
Biomarker-based assessment of the toxicity of the antifungal clotrimazol to the microcrustacean Daphnia magna
2019, Environmental Toxicology and PharmacologyCitation Excerpt :CTZ has been shown to be a potent 6-hydroxylation inhibitor of testosterone in rats that is catalyzed by CYP3A (Turan et al., 2001). It is also a potent in vitro inhibitor of mammalian cytochrome P450, including those responsible for the metabolism of xenobiotics (Sheets et al., 1986; Heuser and Franklin, 1985; Suzuki et al., 2000). The major in vivo metabolite of CTZ is 2-chlorophenylbiphenylmethanol (2CLBPM) resulting from the deamination reaction, which is catalyzed by CYP3A.
Effect of clotrimazole on the pump cycle of the Na,K-ATPase
2008, Biophysical JournalCitation Excerpt :Clotrimazole (CLT) is an imidazole derivative that is usually employed as an antifungal agent (1). It has also been shown to inhibit cell proliferation (2,3) and to affect steroid metabolism (4) and sickle cell dehydration (5). At the molecular level these actions have been attributed to an inhibitory effect on cytochrome P-450 (6,7), SERCA pumps (8,9), and calcium-dependent K+ channels (10–12).
Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors
2004, Chemico-Biological InteractionsCitation Excerpt :In addition, the selectivity of some antifungal imidazoles, CNS-active drugs and NSAID diclofenac in P450 inhibition was also evaluated. The azoles selected are known as potent ligands for the heme ferric iron of P450s [21,22]. Therefore, azole derivatives may be suspected to be nonselective inhibitors of P450 enzymes.
Effects of currently used pesticides in assays for estrogenicity, androgenicity, and aromatase activity in vitro
2002, Toxicology and Applied PharmacologyNoncompetitive mixed-type inhibition of rainbow trout CYP1A catalytic activity by clotrimazole
1999, Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology
- ☆
Supported, in part, by Grants NIGMS 16488 and CA-30253 from the National Institutes of Health, USPHS. J.J.S. was supported, in part, by a USPHS National Research Service Award (1-F32-HD-06596-01) and a Post-doctoral Fellowship from the Chilton Foundation.