Research paperThe role of intestinal flora in metabolism of phenolic sulfate esters
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2019, Saudi Pharmaceutical JournalCitation Excerpt :These end products promote the excretion of ammonia and amines into the feces to relieve hepatic encephalopathy through lowering the pH within the intestine (Elkington et al., 1969; Grundmann, 2010). The latter is metabolized into 4,49-(pyridin-2-ylmethanediyl) diphenol by arylsulfate sulfotransferase of Eubacterium rectale in the colon (Kim and Kobashi, 1986; Kim et al., 1992). However, some anti-allergic drugs, such as diphenhydramine and chlorpheniramine, can cause or aggravate constipation by slowing intestinal peristalsis.
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