Metabolic activation of hydralazine by rat liver microsomes☆
References (22)
- et al.
Biochem. biophys. Res. Commun.
(1978) - et al.
J. Chromat.
(1976) - et al.
J. biol. Chem.
(1964) - et al.
J. biol. Chem.
(1962) - et al.
J. Chromat.
(1986) - et al.
J. biol. Chem.
(1951) J. biol. Chem.
(1983)- et al.
Biochem. biophys. Res. Commun.
(1982) - et al.
J. Lab. clin. Med.
(1970) - et al.
Clin. Pharmac. Ther.
(1980)
Arzneimittel-Forsch.
(1981)
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1993, Chemico-Biological InteractionsMechanistic Investigation of the Time-Dependent Aldehyde Oxidase Inhibitor Hydralazine
2023, Drug Metabolism and DispositionReactive Drug Metabolites
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2005, Drug Metabolism Reviews
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This research was supported in part by NIH Research Grant GM 30261. Part of this material appeared in abstract form [Fedn Proc.44,1624 (1985)]and in a thesis submitted by L. B. L. in partial fulfilment of the requirements for the degree of Doctor of Philosophy in the School of Pharmacy, West Virginia University, 1985.
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Present address: Department of Biomedical Sciences, University of Illinois, College of Medicine at Rockford, 1601 Parkview Ave., Rockford, IL 61107.
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Present address: Mylan Pharmaceuticals, 781 Chestnut Ridge Road, Morgantown, WV 26505.
Copyright © 1987 Published by Elsevier Inc.