Elsevier

Biochemical Pharmacology

Volume 37, Issue 22, 15 November 1988, Pages 4405-4407
Biochemical Pharmacology

Short communication
Sulphation and glucuronidation of paracetamol in human liver: assay conditions

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    Therapeutic doses of APAP of approximately 4 g daily are considered to be safe while overdose produces severe centrilobular liver injury that can lead to fatal fulminant hepatic failure (Yaman et al., 2011). APAP is eliminated almost entirely as nontoxic glucuronic acid and sulfate conjugates when used at therapeutic doses (Pacifici et al., 1988). However, a small proportion of APAP is converted to N-acetyl-p-benzoquinoneimine (NAPQI) by cytochrome P-450 mediated oxidation.

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Present address: Associate Professor in Pharmacology at the Department of General Pathology, Medical School, University of Pisa, Italy.

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