Short communicationSulphation and glucuronidation of paracetamol in human liver: assay conditions
References (16)
Inhibition of acetaminophen glucuron- idation by oxazepam
Biochem Pharmacol
(1976)Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse
Biochem Pharmacol
(1978)- et al.
Human platelet phenol sulphotransfer- ase: Assay procedure, substrate and tissue correlations
Clin Chim Acta
(1981) - et al.
Protein measurement with the folin phenol reagent
J Biol Chem
(1951) - et al.
Phenol sulfotransferases
J Biol Chem
(1979) - et al.
Metabolism of acetamino- phen in hepatocytes isolated from mice and rats of various ages
Drug Metab Dispos
(1985) - et al.
Multiple forms of aryl sulphotransferase for acetaminophen
J Pharm Dyn
(1984) - et al.
Acetaminophen and phenol: Substrates for both a thermostable and a ther- molabile form of human platelet phenol sulfotransferase
J Pharmacol Exp Ther
(1981)
There are more references available in the full text version of this article.
Cited by (27)
The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury
2012, Environmental Toxicology and PharmacologyCitation Excerpt :Therapeutic doses of APAP of approximately 4 g daily are considered to be safe while overdose produces severe centrilobular liver injury that can lead to fatal fulminant hepatic failure (Yaman et al., 2011). APAP is eliminated almost entirely as nontoxic glucuronic acid and sulfate conjugates when used at therapeutic doses (Pacifici et al., 1988). However, a small proportion of APAP is converted to N-acetyl-p-benzoquinoneimine (NAPQI) by cytochrome P-450 mediated oxidation.
Therapeutic effect of S-allylmercaptocysteine on acetaminophen-induced liver injury in mice
2001, European Journal of PharmacologyHigh-performance liquid chromatographic assay for acetaminophen glucuronide in human liver microsomes
2001, Journal of Chromatography B: Biomedical Sciences and ApplicationsFetal hepatic drug elimination
1999, Pharmacology and TherapeuticsIn vitro inhibition of human liver drug metabolizing enzymes by second generation antihistamines
1999, Chemico-Biological Interactions
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Present address: Associate Professor in Pharmacology at the Department of General Pathology, Medical School, University of Pisa, Italy.
Copyright © 1988 Published by Elsevier Inc.