Cytochrome P-450-dependent oxidase activity and hydroxyl radical production in micellar and membranous types of reconstituted systems☆
References (29)
- et al.
Archs Biochem. Biophys.
(1975) - et al.
Tox. Lett.
(1985) - et al.
FEBS Lett.
(1983) - et al.
FEBS Lett.
(1978) - et al.
FEBS Lett.
(1986) - et al.
J. biol. Chem.
(1983) - et al.
J. biol. Chem.
(1984) Trends Pharmac. Sci.
(1986)- et al.
Biochem. Pharmac.
(1986) - et al.
Biochim. biophys. Acta
(1980)
FEBS Lett.
J. biol. Chem.
J. biol. Chem.
Biochem. Pharmac.
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Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease
2015, Advances in PharmacologyCitation Excerpt :However, after binge and chronic alcohol drinking with higher BAC up to ~ 100 mM, as observed in some alcoholics (Lindblad & Olsson, 1976), induced CYP2E1 becomes important in ethanol metabolism. Unlike other P450 enzymes, CYP2E1, a loosely bound enzyme to the ER membrane, exhibits NADPH-oxidase activity, thus producing ROS during its catalytic cycle (Ekström & Ingelman-Sundberg, 1989; Terelius & Ingelman-Sundberg, 1988). The ROS include superoxide anion, hydroxyethyl radical, and hydrogen peroxide, depending on the local environment and pre-existing conditions.
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A survey of reactive oxygen species and their role in dermatology
1997, Journal of the European Academy of Dermatology and Venereology
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Supported by grants from Magn. Bergvalls Stiftelse and from The Swedish Medical Research Council.