Comparative drug metabolism of diazepam in hepatocytes isolated from man, rat, monkey and dog
References (27)
Preparation of isolated rat liver cells
Methods Cell Biol
(1976)- et al.
Simultaneous determination of diazepam and its metabolites N-desmethyl diazepam, oxydiazepam and oxazepam in plasma and urine of man and dog by means of high pressure liquid chromatography
J Chromatogr
(1979) - et al.
Metabolism of diazepam in dogs: transformation to oxazepam
Arch Bichem Biophys
(1965) - et al.
Metabolism of diazepam in rabbits
Arch Biochem Biophys
(1964) - et al.
Diazepam metabolism in cultured hepatocytes from rat, rabbit, dog, guinea pig and man
Drug Metab Disp
(1987) - et al.
Drug metabolism activity of freshly isolated human hepatocytes
Br J Clin Pharmacol
(1983) - et al.
Drug metabolism and effects of carcinogens in cultured hepatic cells
Pharmacol Rev
(1980) - et al.
A model describing the disposition of phenytoin in isolated rat hepatocytes
Biopharmaceutics Drug Disp
(1984) The metabolism of drugs and other foreign compounds in suspensions of isolated rat hepatocytes
Ann NY Acad Sci
(1980)- et al.
Changes in the concentration of seven forms of cytochrome P450 in primary cultures of adult rat hepatocytes
Mol Pharmacol
(1984)
Comparison of amphetamine metabolism using isolated hepatocytes from five species including human
J Pharmacol Exp Ther
Comparative metabolism of tolbutamide by isolated hepatocytes from rat, rabbit, dog and squirrel monkey
Drug Metab Disp
Pharmacokinetics and plasma binding of diazepam in man, dog, rabbit, guinea pig and rat
J Pharmacol Exp Ther
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2017, Pharmacological ReportsCitation Excerpt :In the liver diazepam is metabolized to three main active metabolites: desmethyldiazepam, oxazepam and temazepam. The metabolism of diazepam depends on the species, age, sex, presence of liver diseases, genetic variability and the exposure to inducers or inhibitors of cytochrome P450 (CYP450) [4]. The 3-hydroxy-3-methylglutaryl-coenzyme (HMG-CoA) reductase inhibitors, commonly known as statins, are the most potent and most widely used cholesterol lowering drugs.
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2016, Analytical BiochemistryCitation Excerpt :Ferric nitrilotriacetic acid [Fe(III)NTA] stock solution (20 mM) was prepared by mixing 5 ml of 0.1 M Fe(NO3)3 in 0.1 M HCl and 0.2 M NaNTA, filling up to 30 ml, and adjusting the pH to 7.4 with 1 M NaCO3. Primary cells were prepared freshly in-house by a two-step procedure for liver perfusion [27,28] and used in suspension. Incubation was performed at 37 °C in humidified atmosphere (5% CO2/95% air) in 96-well plates at a cell concentration of 1 million/ml and stopped after 1 or 3 h by precipitation with acetonitrile that contained the internal standard (PD2-d4 at a concentration of 1 ng/ml to reach a final concentration of 0.42 ng/ml).
Feline hepatic biotransformation of diazepam: Differences between cats and dogs
2015, Research in Veterinary ScienceCitation Excerpt :All three metabolites are pharmacologically active. Nordiazepam appears to be the principal metabolite of diazepam in man and dogs, although species-specific differences in the relative quantities of these metabolites have been observed previously (Vree et al., 1979; Chenery et al., 1987; Seddon et al., 1989). The lipophilic metabolites temazepam and oxazepam are excreted as phase II glucuronides in the urine (Schwartz et al., 1965; Vree et al., 1979).
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