Chiral inversion of 2-arylpropionic acid non-steroidal anti-inflammatory drugs—1: In vitro studies of ibuprofen and flurbiprofen
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2015, Food and Chemical ToxicologyCitation Excerpt :Ibuprofen (IBU) is a drug of the group of nonsteroidal anti-inflammatory drugs marketed in racemic form (Itoh et al., 1997). The unidirectional chiral inversion of (−)-(R)-IBU to (+)-(S)-IBU occurs in humans, rats and other animal species (Kaiser et al., 1976; Knihinicki et al., 1989; Rudy et al., 1991; Sattari and Jamali, 1994). The metabolism of ibuprofen in humans occurs in two ways, that is CYP2C-mediated oxidation and conjugation with glucuronic acid and (Glowka and Karazniewicz, 2007).
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