Metabolism of lidocaine by purified rat liver microsomal cytochrome P-450 isozymes
References (30)
- et al.
Anti-arrhythmic effects of lidocaine metabolites
Am Heart J
(1974) - et al.
Precursor-metabolite interaction in the metabolism of lidocaine
J Pharm Sci
(1984) - et al.
Age associated alteration of lidocaine metabolism is position selective
Biochem Biophys Res Commun
(1985) - et al.
Simultaneous purification of multiple forms of rat liver microsomal cytochrome P-450 by high-performance liquid chromatography
Biochim Biophys Acta
(1985) - et al.
Purification and characterization of liver microsomal cytochrome P-450 from untreated male rats
Biochim Biophys Acta
(1987) - et al.
Simultaneous quantitation of lidocaine and its four metabolites by high-performance liquid chromatography: application to studies on in vitro and in vivo metabolism of lidocaine in rats
J Pharm Sci
(1985) - et al.
Characterization of three highly purified cytochromes P-450 from hepatic microsomes of adult male rats
J Biol Chem
(1984) - et al.
Sex difference of cytochrome P-450 in the rat: purification, characterization, and quantitation of constitutive forms of cytochrome P-450 from liver microsomes of male and female rats
Arch Biochem Biophys
(1983) - et al.
Testosterone metabolism by cytochrome P-450 isozymes RLM3 and RLM5 and by microsomes
J Biol Chem
(1983) - et al.
Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene
J Biol Chem
(1979)
Phenobarbital-induced rat liver cytochrome P-450
J Biol Chem
Purification and characterization of a minor form of hepatic microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls
Arch Biochem Biophys
Hepatic microsomal cytochrome P-450 from rats treated with isosafrole
J Biol Chem
Purification and characterization of two constitutive cytochromes P-450 (F-1 and F-2) from adult female rats: identification of P-450F-1 as the phenobarbital-inducible cytochrome P-450 in male rat liver
Biochim Biophys Acta
Differential expression and function of three closely related phenobarbital-inducible cytochrome P-450 isozymes in untreated rat liver
Arch Biochem Biophys
Cited by (56)
Dietary-Induced Obesity, Hepatic Cytochrome P450, and Lidocaine Metabolism: Comparative Effects of High-Fat Diets in Mice and Rats and Reversibility of Effects With Normalization of Diet
2020, Journal of Pharmaceutical SciencesCitation Excerpt :Hence, inhibiting CYP3A might perhaps not only decrease its formation from lidocaine but also inhibit its sequential metabolism, leading to no difference in this metabolite in a closed microsomal system. In microsomes isolated from the male rat liver, it has been reported that MEGX maximum formation rate was 4.84 nmol/min/mg, which is consistent to what we found in our male rats (4.6 nmol/min/mg).41 The sex difference seen in MEGX formation in the immunoinhibition experiment (Fig. 8) was observed here as well as in the microsomal experiments used to identify kinetic constants (Table 4).
Mechanism of aromatic hydroxylation of lidocaine at a Pt electrode under acidic conditions
2017, Electrochimica ActaCitation Excerpt :We have extensively studied alternative electrochemical methods for the synthesis of specific oxidation products of the local anesthetic drug lidocaine. Lidocaine is oxidized in vivo to the aromatic hydroxylation products 3- and 4-hydroxylidocaine, and can also undergo benzylic hydroxylation, N-dealkylation and N-oxidation reactions [21,22]. By adjusting the electrochemical parameters, a certain degree of product selectivity can be achieved.
Optimization of reaction parameters for the electrochemical oxidation of lidocaine with a design of experiments approach
2015, Electrochimica ActaCitation Excerpt :The local anesthetic lidocaine (Fig. 1) has been used as a model compound for the study of oxidative metabolism by electrochemistry. The in vivo reactions, catalyzed by enzymes of the cytochrome P450 family, are N-dealkylation and N-oxidation of the tertiary amine, aromatic hydroxylation at the 3 and 4 positions and benzylic hydroxylation (Fig. 1) [11–14]. Previously, our group reproduced most of these reactions by various electrochemical approaches.
Role of the alanine at position 363 of cytochrome P450 2B2 in influencing the NADPH- and hydroperoxide-supported activities
1998, Archives of Biochemistry and Biophysics
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