Distribution of cytochromes P-450, cytochrome b5, and nadph-cytochrome P-450 reductase in an entire human liver
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Cited by (38)
Comprehensive assessment of Cytochrome P450 reactions: A multiplex approach using real-time ESI-MS
2015, Biochimica et Biophysica Acta - General SubjectsCitation Excerpt :In fact, the effect of Cyt b5 on CYP(3A4) activity is well studied. However, depending on the used substrate and assay conditions the behavior of Cyt b5 is contradictory discussed in the literature [51,60–63]. Lee and Goldstein investigated the CYP3A4 activity with different Cyt b5/CYP ratios.
Comparable constitutive expression and activity of cytochrome P450 between the lobes of the porcine liver
2014, Toxicology in VitroCitation Excerpt :Heterogeneous distribution of CYP450 between the different lobes has been determined in rats, both constitutive and after drug and xenobiotic treatment (Sumner and Lodola, 1987; Matsubara et al., 1982). In contrast, differences have not been observed in human and dog livers (Nishibe et al., 1998; Watkins et al., 1990). To our knowledge only one study has previously investigated the intra-hepatic variation of porcine CYP450 (Hoogenboom et al., 1989).
Drug-drug interaction mediated by inhibition and induction of P-glycoprotein
2003, Advanced Drug Delivery ReviewsFetal hepatic drug elimination
1999, Pharmacology and Therapeutics
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