High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat
References (36)
- et al.
Immunochemical relatedness of rat hepatic microsomal cytochromes P-450c and P-450d
J Biol Chem
(1982) - et al.
Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics
J Biol Chem
(1983) - et al.
Induction of specific cytochrome P-450 isozymes by methylenedioxyphenyl compounds and antagonism by 3-methylcholanthrene
Arch Biochem Biophys
(1985) - et al.
Immunochemical quantitation of cytochrome P-450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats
J Biol Chem
(1983) - et al.
Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital and, 3-methylcholanthrene
J Biol Chem
(1979) - et al.
Characterization of nine monoclonal antibodies against rat hepatic cytochrome P-450c. Delineation of at least five spatially distinct epitopes
J Biol Chem
(1984) - et al.
Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes tor genetic polymorphism in oxidative drug metabolism
J Biol Chem
(1985) - et al.
Proteins and polypeptides as antigens
Methods Enzymol
(1980) - et al.
Biophasic O-deethylation of phenacetin and 7-ethoxycoumarin by human and rat liver microsomal fractions
Biochem Pharmacol
(1981) - et al.
Antibodies to a synthetic peptide that react specifically with a common surface region on two hydrocarbon-inducible isoenzymes of cytochrome P450 in rat
Biochem Pharmacol
(1988)
Purification of cytochrome P-450, NADPH-cytochrome P-450 reductase, and epoxide hydratase from a single preparation of rat liver microsomes
Arch Biochem Biophys
A monoclonal antibody raised to rat liver cytochrome P-448 (form c) which recognises an epitope common to many other forms of cytochrome P-450
Biochem Pharmacol
Hepatic microsomal cytochrome P-450 from rats treated with isosafrole. Purification and characterization of four enzymic forms
J Biol Chem
Monoclonal antibodies to rabbit liver cytochrome P-448
Life Sci
A dot-immunobinding assay for monoclonal and other antibodies
Arch Biochem
Reconstituted mammalian mixed-function oxidases: requirements, specificities and other properties
Pharmacol Ther
Protein measurement with the Folin phenol reagent
J Biol Chem
The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
J Biol Chem
Cited by (57)
Molecular cloning and functional analysis of cytochrome P450 1A2 from Japanese monkey liver: Comparison with marmoset cytochrome P450 1A2
2005, Chemico-Biological InteractionsCitation Excerpt :Fluorescence of the supernatant was measured at 580/600 nm (excitation/emission wavelength) using a Hitachi F-4500 fluorescence spectrophotometer. PN O-dethylase activity was measured by a published method [14] with modifications. Briefly, the ice-cold incubation mixture (500 μl) in a brown glass conical tube (10 ml) with a stopper contained 5 mM G-6-P, 1 IU of G-6-P dehydrogenase, 5 mM MgCl2, 0.1 mM EDTA and 100 μM PN in 100 mM potassium phosphate buffer (pH 7.4).
Cytochrome P450 isoenzymes involved in rat liver microsomal metabolism of californine and protopine
2004, European Journal of PharmacologyStudy of P450 function using gene knockout and transgenic mice
2003, Archives of Biochemistry and BiophysicsCitation Excerpt :Phenacetin is metabolized by P450 to the widely used drug actetaminophen that itself can be converted to a toxic metabolite by P450s as described above. In vitro studies indicate that CYP1A2 metabolizes phenacetin [27]. To determine whether CYP1A2 is involved in phenacetin toxicity, the CYP1A2 null mice were examined by feeding diets containing phenacetin [28].
Identification of Inhibitory Component in Cinnamon -O-Methoxycinnamaldehyde Inhibits CYP1A2 and CYP2E1
2002, Drug Metabolism and PharmacokineticsInduction of Cytochrome P450 1A1 in Mice by Repeated Oral Administration of Propranolol
2002, Drug Metabolism and PharmacokineticsCatalytic and immunochemical properties of hepatic cytochrome P450 1A in three avian species treated with β-naphthoflavone or isosafrole
2001, Comparative Biochemistry and Physiology - C Toxicology and Pharmacology
- ‡
Present address: College of Pharmacy, Rutgers University, Busch Campus, Piscataway, NJ 08855, U.S.A.