Induction of cytochrome P450 activities by polychlorinated biphenyls in isolated mouse hepatocytes: Influence of Ah-phenotype and iron
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Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR)
2015, ToxicologyCitation Excerpt :In addition to the chemicals used to create the biomarker (TCDD and B[a]P), a number of chemicals were found to significantly activate AhR. The chemicals include the known activators 7,12-dimethylbenzanthracene (DMBA) (Galvan et al., 2005) and aroclor 1254 (Madra and Smith, 1992; Schaap et al., 2012) (Fig. 5B). In our study, male BALB/C mice fed a diet supplemented with 0.5% quercetin showed activation of AhR (from GSE38136).
Porphyria Caused by Chlorinated AH Receptor Ligands and Associated Mechanisms of Liver Injury and Cancer
2012, The Porphyrin Handbook: Medical Aspects of PorphyrinsUroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: Relation to the role of CYP1A2 in human porphyria cutanea tarda
2003, Biochemical PharmacologyCitation Excerpt :These findings also indicate that cells other than primary hepatocytes have the capacity to accumulate URO, provided they also express sufficient CYP1A2. Previously, only primary chick and mouse hepatocytes were shown to accumulate URO in a CYP1A-dependent manner [16,19,27,28]. In addition to showing that transfected cells expressing either mouse or human CYP1A2 accumulated URO when incubated with ALA, we also measured the UROX activity of microsomes from these cells.
Captan impairs CYP-catalyzed drug metabolism in the mouse
1999, Chemico-Biological Interactions