Research paperThe effect of enzyme induction on the cytochrome P450-mediated bioactivation of carbamazepine by mouse liver microsomes
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Transcriptome analysis of the brain of the sea bream (Sparus aurata) after exposure to human pharmaceuticals at realistic environmental concentrations
2017, Marine Environmental ResearchCitation Excerpt :In humans, Brämswig et al. (2002) postulated enzyme-inducing effects of CBZ responsible for changes in lipoprotein concentrations as well as for changes in thyroid and sex hormone concentrations (Connell et al., 1984a,b; Luoma et al., 1985). In addition, CBZ is also known to be a powerful inducing agent of cytochrome P-450 enzymes (Isojärvi et al., 1991; Kerr et al., 1994; Pirmohamed et al., 1992), and its effects on lipoproteins have been largely attributed to its enzyme-inducing action (Luoma et al., 1980; Connell et al., 1984b). Accordingly, considering the significant over-expression of putative “Thyroid hormone receptor and of the putative “Brain cytochrome P450 aromatase (CYP19; see Supplementary file 1), this study suggests similar mechanism of action (MOA) of CBZ in gilthead seabream brain.
Effects of carbamazepine and two of its metabolites on the non-biting midge Chironomus riparius in a sediment full life cycle toxicity test
2016, Water ResearchCitation Excerpt :In addition, it caused teratogenic effects in a mouse model and also formed covalent protein adducts in human plasma and liver microsomes, resulting in EP-CBZ being suggested as the cause of these adverse effects (Bennett et al., 1996; Bu et al., 2005). However, cytotoxicity of CBZ showed to increase under trichloropropene oxide treatment, an epoxide hydrolase inhibitor which is also responsible for arene oxide detoxification (Pirmohamed et al., 1992; Riley et al., 1989). On this basis, it was hypothesized that especially arene oxides but also other reactive metabolites of EP-CBZ might be responsible for the toxic effects observed and not EP-CBZ itself (Santos et al., 2008; Shear and Spielberg, 1988).
Anticonvulsant agents
2013, Drug-Induced Liver DiseaseEffect of pregnane X receptor (PXR) prototype agonists on chemoprotective and drug metabolizing enzymes in mice
2011, European Journal of PharmacologyCitation Excerpt :Cytochrome P450 isoform 3A (CYP3A), UDPGT, and GST are known target genes for PXR agonists in human (Duret et al., 2006). In mice, PCN, dexamethasone and SPL were reported to increase Cyp3a mRNA in liver (Maglich et al., 2002; Xu et al., 2005), while, dexamethasone alone increased CYP3A activity (Pirmohamed et al., 1992; Xu et al., 2005). PCN had no effect on the transcript level of Cyp1a1 (Maglich et al., 2002).