Research paperA multispecific uptake system for taurocholate, cardiac glycosides and cationic drugs in the liver
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2000, Kidney InternationalCitation Excerpt :These findings support the electrogenic facilitated transport of organic cations in renal basolateral membranes Figure 2. Studies using isolated rat hepatocytes have suggested the existence of two different transport systems for organic cations: a type 1 system mediating uptake of small hydrophilic organic cations such as TEA, cimetidine, procainamide and guanidine, and a type 2 system mediating uptake of hydrophobic organic cations such as quinidine, quinine, d-tubocurarine, vecuronium, and cardiac glycosides88,89. Most substrates of the type 2 system have potent inhibitory effects on the type 1 system.
Regulation of organic anion and drug transporters of the sinusoidal membrane
1999, Journal of HepatologyMembrane localization of the electrogenic cation transporter rOCT1 in rat liver
1998, Biochemical and Biophysical Research CommunicationsStereoselective inhibition by the diastereomers quinidine and quinine of uptake of cardiac glycosides into isolated rat hepatocytes
1998, Journal of Pharmaceutical Sciences
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