Cocaine hepatotoxicity: Two different toxicity mechanisms for phenobarbital-induced and non-induced rat hepatocytes
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Cited by (28)
Cocaine-Induced Breakdown of the Blood-Brain Barrier and Neurotoxicity
2009, International Review of NeurobiologyCitation Excerpt :However, a direct demonstration of cocaine-induced BBB leakage in vivo situation is still lacking and requires further investigation. Several in vitro studies demonstrated cytotoxic effects of cocaine in non-neural cells, for example, liver, aorta, adrenal, and kidney probably through generation of free radicals (Barroso-Moguel et al., 1995; Fan et al., 2009; Jover et al., 1993; Lepsch et al., 2009; Powers et al., 1992; Schreiber and Formal, 2007; Welder, 1992; Yao et al., 2009). Based on these results, it appears that cocaine could also induce neurotoxicity in the CNS using identical mechanisms.
Oral cocaine produces dose-related hepatotoxicity in male mice
2001, Toxicology LettersEffect of N-acetylcysteine and deferoxamine on endogenous antioxidant defense system gene expression in a rat hepatocyte model of cocaine cytotoxicity
2000, Biochimica et Biophysica Acta - Molecular Cell ResearchIncreased toxicity of cocaine on human hepatocytes induced by ethanol: Role of GSH
1999, Biochemical Pharmacology
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