Phase I and phase II metabolism of lithocholic acid in hepatic acinar zone 3 necrosis: Evaluation in rats by combined radiochromatography and gas-liquid chromatograpry-mass spectrometry
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Cited by (22)
Application of gas chromatography-triple quadrupole mass spectrometry to the determination of sterol components in biological samples in consideration of the ionization mode
2013, BiochimieCitation Excerpt :A crucial factor is derivatization. Some authors recommend the derivatization to methyl esters with subsequent trimethylsilylation [19,34,35] or methylation and acetylation [36,37]. We decided to convert the hydroxyl groups to trimethylsilylether groups expecting benefits for the MS precursor/product ion function as seen for the oxysterol species.
Isolation and chemical synthesis of a major, novel biliary bile acid in the common wombat (Vombatus ursinus): 15α-hydroxylithocholic acid
2007, Journal of Lipid ResearchCitation Excerpt :If this hypothesis is correct, the wombat resembles other rodents [mouse (9–12, 32), rat (33–38), and guinea pig (39, 40)], species in which lithocholic acid is efficiently hydroxylated at C-6, C-7, or both during hepatocyte transport. Sulfation (36) and glucuronidation (35, 37) of lithocholic acid also occur in these species, but to a much smaller extent. N-Acylamidation (mostly with taurine) of the dihydroxy and trihydroxy metabolites of lithocholic acid occurs, but their sulfates and glucuronides have not been reported.
ME3738 protects against lithocholic acid-induced hepatotoxicity, which is associated with enhancement of biliary bile acid and cholesterol output
2007, European Journal of PharmacologyPreventive effect of silymarin against taurolithocholate-induced cholestasis in the rat
2003, Biochemical PharmacologyCitation Excerpt :Biliary excretion of TMDC, which was also not detectable in basal conditions, reached a maximum at 40–60 min after TLC administration in TLC-treated rats, and SIL pretreatment was also able to accelerate its biliary output, particularly during the first collection periods (Fig. 4, lower panel); this led to a significant increment in the cumulative biliary output of TMDC of 70% (Fig. 4, lower panel, inset). Cumulative biliary output of taurine conjugates of CDC, β-MC and hyodeoxycholate, resulting from TLC phase I metabolism [32,33], as discriminated from changes in their excretions from endogenous sources using the non-TLC metabolite, cholate, as an internal standard [32], tended to be higher in SIL+TLC group than in rats only treated with TLC, but these results did not reach statistical significance (data not shown). The main finding of the present work is that the hepatoprotector SIL significantly prevents the acute cholestasis induced by a single, i.v. dose of TLC.
Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity
2003, Journal of Biological ChemistryBiliary excretion of temocapril in zone 1- and zone 3-injured rat
2001, Hepatology Research