Short communicationMorin: A wood pigment that protects three types of human cells in the cardiovascular system against oxyradical damage
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The flavonoid morin alleviates nuclear deformation in aged cells by disrupting progerin-lamin A/C binding
2021, Journal of Functional FoodsCitation Excerpt :Morin required a concentration four times higher than that of the synthetic compound JH4 to prevent nuclear deformation in HGPS cells. However, morin is advantageous as a daily food ingredient because of its potentially low toxicity; it is known to be harmless at around 300 mg/kg of body weight/day in mice (Wu, Zeng, Wu, & Fung, 1994; Yugarani, Tan, Teh, & Das, 1992). In our previous study, we demonstrated that morin directly inhibited the activity of GSK3β, using biochemical and complex crystal structures (Gong, Park, Kim, Piao, Lee, Jo, et al., 2011; K. Kim et al., 2018).
Morin attenuates STZ-induced diabetic retinopathy in experimental animals
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