Research paperResponse of [Ah] battery genes to compounds that protect against menadione toxicity
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2013, European Journal of Medicinal ChemistryCitation Excerpt :Compounds H290/51 and DHII were shown also to affect the activity of thyroid peroxidase and regulation of aromatic hydrocarbon gene battery enzymes, affecting the glutathione levels in mouse hepatoma cell lines, both related to redox processes in vivo [68,69]. In a sensitive and resistant mouse hepatocyte line, DHII also showed protection from menadione (vitamin K3) toxicity [70,71]. Lipofuscin (LF) is finely granular yellow-brown pigment granules composed of lipid-containing residues of lysosomal digestion.
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2003, Journal of Biological ChemistryCitation Excerpt :The microsomal fractions were stored at –70 °C until use. SDS-polyacrylamide gel electrophoresis and immunoblot analyses were performed according to previously published procedures (28). Microsomal proteins were separated by 7.5% gel electrophoresis and electrophoretically transferred to nitrocellulose paper.
Involvement of the electrophile responsive element and p53 in the activation of hepatic stellate cells as a response to electrophile menadione
2003, Archives of Biochemistry and BiophysicsCitation Excerpt :Similarly, induction of several defense mechanisms has been identified in yeast as a response to oxidative stress [24,25]. We have previously shown that pretreatment of mouse hepatoma Hepa-1 cells with 25 μM tert-butylhydroquinone or 10 μM menadione itself generated substantial protection against toxicity produced by subsequent menadione exposure [26]. The suppressed sensitivity was associated with increased expression of the phase II [Ah] battery genes, which are mediated by the EPRE.