Research paperInhibition of microsomal cytochromes P450 in rat liver by the tricyclec antidepressant drug desipramine and its primary oxidized metabolites☆
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Cited by (17)
Antidepressants’ effects on testosterone and estrogens: What do we know?
2021, European Journal of PharmacologyCitation Excerpt :N-Monoalkyl substituted tricyclic antidepressants like desipramine are known to undergo cytochrome (P450) -mediated biotransformation in the liver to produce inhibitory metabolite-intermediate complexes with the enzyme. An in vitro study indicated that inhibition of testosterone hydroxylation pathways was enhanced by prior incubation of desipramine with NADPH and rat liver microsomes (McNeil and Murray, 1996). There were no preclinical and clinical studies regarding desipramine's effects on testosterone.
Effect of antidepressant drugs on cytochrome P450 2C11 (CYP2C11) in rat liver
2013, Pharmacological ReportsCitation Excerpt :On the other hand, some earlier studies showed that tricyclic antidepressants and fluoxetine formed reactive/intermediate metabolites, which irreversibly inactivated a few CYP isoforms (CYP2C11, 2D, 3A, 2A). Such an effect was observed during prolonged incubation in vitro with high concentrations of antidepressants, or after in vivo administration of high doses of the drugs [5, 27, 28, 30, 31], and – in some cases – also after therapeutic concentrations following a 24-h exposure to antidepressants in vivo [11, 18]. Antidepressant drugs increase monoaminergic transmission in the brain, which in turn affects the ‘hypothalamo-pituitary-adrenal’ and ‘hypothalamo- -pituitary (growth hormone)-hepatic’ axes [41, 42]; these axes may then affect the expression of many CYP isoforms [9, 23, 48].
Direct and indirect interactions between antidepressant drugs and CYP2C6 in the rat liver during long-term treatment
2006, European NeuropsychopharmacologyCitation Excerpt :Earlier studies showed that tricyclic antidepressants and fluoxetine formed reactive/intermediate metabolites, which irreversibly inactivated a few CYP isoforms (CYP2C11, 2D, 3A, 2A). That effect was observed during prolonged incubation in vitro with high antidepressant concentrations or after in vivo administration of high drug doses (Murray and Field, 1992; Bensoussan et al., 1995; Masubuchi et al., 1995; McNeil and Murray, 1996; Murray and Murray, 2003), and in some cases also at therapeutic concentrations in vivo after 24-h exposure to antidepressants (Daniel et al., 2002; Haduch et al., in press). The latter effect persisted during chronic treatment.
Separation and detection methods for covalent drug-protein adducts
2003, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesMetabolism-dependent stimulation of reactive oxygen species and DNA synthesis by cyclosporin A in rat smooth muscle cells
1999, Free Radical Biology and Medicine
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This work was supported by a grant from the Australian National Health and Medical Research Council.