ArticleObservations on the metabolism of the psychotomimetic indolealkylamines: Implications for future clinical studies☆
References (19)
- et al.
Metabolism of 5-methoxy-N,N-dimethyltryptamine-14C in the rat
Biochem Pharmacol
(1969) - et al.
A gas chromatographic procedure for determining N,N-dimethyltryptamine and N-monomethyltryptamine in urine using a nitrogen detector
Biochem Med
(1977) - et al.
Mass fragmentographic quantification of urinary N,N-dimethyltryptamine and bufotenm
J Chromatogr
(1979) - et al.
Increased urinary excretion of bufotenin by violent offenders with paranoidsymptoms and family violence
Lancet
(1984) - et al.
Metabolism of bufotenin-2-C14 in human volunteers
Life Sci
(1976) - et al.
The ion pair extraction, purification and liquid chromatographic analysis of indolealkylamines in human urine
Anal Biochem
(1983) - et al.
Separation of the indolealkylamines and their analogous tetrahydro-ß-carbolines by liquid chromatography
J Chromatogr Biomed Applic
(1983) - et al.
Study of metabolism of psychotomimetic indolealkylamines by rat extracts using liquid chromatography
Biochem Pharmacol
(1987) - et al.
In vivo metabolism of 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine in the rat
Biochem Pharmacol
(1987)
There are more references available in the full text version of this article.
Cited by (25)
Effects of monoamine oxidase inhibitor and cytochrome P450 2D6 status on 5-methoxy-N,N-dimethyltryptamine metabolism and pharmacokinetics
2010, Biochemical PharmacologyCitation Excerpt :In addition, blockage of MAO-mediated deamination metabolism of 5-MeO-DMT may cause variation in other metabolic pathways. The prior treatment of MAOI iproniazid or pargyline has been shown to redirect the metabolism of 5-MeO-DMT, resulting in higher levels of other metabolites in rat urine [32,33]. Compared with 5-MeO-DMT alone, co-incubation of 5-MeO-DMT with harmaline sharply increased the production of active metabolite bufotenine in human CYP2D6 EM hepatocytes (Fig. 2).
Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats
2006, Pharmacology Biochemistry and BehaviorDistribution of the hallucinogens N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine in rat brain following intraperitoneal injection: Application of a new solid-phase extraction LC-APcI-MS-MS-isotope dilution method
2001, Journal of Chromatography B: Biomedical Sciences and ApplicationsAyahoasca: An experimental psychosis that mirrors the transmethylation hypothesis of schizophrenia
1999, Journal of EthnopharmacologyAltered consciousness states and endogenous psychoses: A common molecular pathway?
1997, Schizophrenia ResearchNialamide, an MAO inhibitor, increases urinary excretion of endogenously produced bufotenin in man
1992, Biological Psychiatry
- ☆
Supported in part by the National Health and Medical Research Council of Australia.
Copyright © 1990 Published by Elsevier Inc.