Determination of rat cerebral cortical blood volume changes by capillary mean transit time analysis during hypoxia, hypercapnia and hyperventilation
References (34)
- et al.
Alterations in perfused capillary morphometry in awake vs anesthetized brain
Brain Research
(1986) - et al.
Mean residence time-theoretical development, experimental determination, and practical use in tracer analysis
Math. Biosci.
(1984) - et al.
Micro-circulation velocity changes under hypoxia in brain, muscles, liver, and their physiological significance
Microvasc. Res.
(1985) - et al.
Validity of cerebral blood flow measurements obtained with quantitative tracer techniques
Brain Res. Rev.
(1980) - et al.
Oxygen insufficiency during hypoxic hypoxic in rat brain cortex
Brain Research
(1984) - et al.
Quantitative capillary topography and blood flow in the cerebral cortex of cats: and in vivo microscopic study
Brain Research
(1981) - et al.
A proof of the occupancy principle and the mean-transit-time theorem for compartmental models
Math. Biosci.
(1984) The blood-brain barrier
Circ. Res.
(1985)- et al.
Infra-red technique for cerebral blood flow: comparison with133Xenon clearance
Neurol. Res.
(1981) Reflectometric mapping of microregional blood flow and blood volume in the brain cortex
J. Cereb. Blood Flow Metab.
(1982)
Induced hemodilution detected by reflectometry for measuring microregional blood flow and blood volume in cat brain cortex
Am. J. Physiol.
The effect of O2 and CO2 on Prostaglandin levels in the cat cerebral cortex
Circ. Res.
Effect of hypoxia on percent arteriolar and capillary beds perfused in the rat brain
J. Appl. Physiol.
The nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure, and normal values
J. Clin. Invest.
Applied Regression Analysis and Other Multivariable Methods
Local cerebral blood volume in head-injured patients
J. Neurosurg.
Regional studies of blood-brain barrier transport of glucose and leucine in awake and anesthetized rats
J. Cereb. Blood Flow Metab.
Cited by (105)
Fundamental constraints of vessels network architecture properties revealed by reconstruction of a rat brain vasculature
2019, Mathematical BiosciencesDrug Delivery to the Brain: Pharmacokinetic Concepts
2017, Nanotechnology Methods for Neurological Diseases and Brain Tumors: Drug Delivery across the Blood-Brain BarrierLaminar microvascular transit time distribution in the mouse somatosensory cortex revealed by Dynamic Contrast Optical Coherence Tomography
2016, NeuroImageCitation Excerpt :Due to the incoherent nature of fluorescence emission, fluorescence imaging is not affected by speckle noise and has lower signal variance. These results indicate that although speckle increases the noise in the concentration curves, Intralipid kinetics are highly correlated to those of a standard fluorescent plasma tracer (Shockley and LaManna, 1988) at the cortical surface, supporting the application of DyC-OCT to measure transit times. Further validation of DyC-OCT was performed by comparing the arrival times from two consecutive injections in the same field of view in the same mouse brain.
RBC velocities in single capillaries of mouse and rat brains are the same, despite 10-fold difference in body size
2010, Brain ResearchCitation Excerpt :It represents that the smaller the animal, the higher the volume rate of blood flow. Mammalian cerebral blood volume appears to be constant, resulting that mean transit time should decrease with decreasing brain size (Shockley and LaManna, 1988). Therefore, since the RBC velocity distribution of mice is similar with that of rats, the capillary length may be shorter in smaller animals.