A new class of inhibitory cytochrome P-450 complexes formed during metabolism: A comparison with amphetamine and SKF 525-A type complexes
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Cited by (23)
Interaction of mycobacterium tuberculosis CYP130 with heterocyclic arylamines
2009, Journal of Biological ChemistryCitation Excerpt :Upon enzymatic reduction of the CYP130-nitro analog mixture by the spinach ferredoxin/NADP+-ferredoxin reductase system under strict anaerobic conditions, a slow transition from the resting ferric ligand-free form to a ferric arylamine-bound form was observed (supplemental Fig. S4). In contrast to the liver microsome P450 preparations under similar anaerobic conditions (22–24), no formation of the nitrosoarene intermediate with a spectral feature at 454 nm has been detected. A control experiment, in which the nitro compound was preincubated with spinach ferredoxin/NADP+-ferredoxin reductase and NADPH for 60 min prior to the addition of ferric CYP130, confirmed that the formation of the amine form was due to the action of CYP130.
Relationship between molecular structure and cytochrome P<inf>450</inf>‐metabolic intermediate complex formation, studied with orphenadrine analogues
1984, Journal of Pharmaceutical SciencesMechanism of the inhibitory action of isoniazid on microsomal drug metabolism
1981, Biochemical PharmacologyAlterations in mouse liver monooxygenases by benzothiadiazoles
1981, Biochemical Pharmacology
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