Metabolism of 2,4′,5-trichlorobiphenyl: Enrichment of hydroxylated and methyl sulphone metabolites in the uterine luminal fluid of pregnant mice

doi:10.1016/0009-2797(82)90027-8

Chemico-Biological Interactions

Volume 40, Issue 1, May 1982, Pages 45-56

https://doi.org/10.1016/0009-2797(82)90027-8 Get rights and content

Abstract

Autoradiography of 2,4′,5-trichloro-[¹⁴C]biphenyl ([¹⁴C]triCB) in mice at different stages of gestation indicated a strong accumulation of radioactivity in the uterine luminal fluid at gestation day 9 and later. From day 10 an uptake of radioactivity occurred also in the yolk sac epithelium. In order to identify the suspected metabolites in the fluid pregnant mice were dosed with unlabelled triCB on gestation day 9. Gas chromatographic (GC) and mass fragmentographic (MF) analysis of extracts of uterine fluid obtained on day 12 showed that hydroxylated, methyl sulphone and conjugated metabolites were present in the fluid. The unchanged triCB could not be detected in the extracts of the fluid. The site of release of the metabolites to the fluid may be the endometrium or, possibly, the yolk sac epithelium. The mechanism behind the concentration of water-insoluble methyl sulphone and hydroxylated metabolites of triCB in an aquatic phase is discussed.

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Metabolism of 2,4′,5-trichlorobiphenyl: Enrichment of hydroxylated and methyl sulphone metabolites in the uterine luminal fluid of pregnant mice

Abstract

The metabolism of chlorobiphenyls — a review

Chemosphere

Sulfur-containing metabolites of 2,2′,5,5′-tetrachlorobiphenyl, a major component of commercial PCBs

Chem. Pharm. Bull.

Sulfur-containing metabolites of chlorobiphenyl isomers, a comparative study

J. Agric. Food Chem.

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Toxicol. Appl. Pharmacol.

Antropogenic substances in seal from the Baltic: methylsulphone metabolites of PCB and DDE

Ambio

Qualitative and quantitative determination of methylsulphone metabolites of polychlorinated biphenyls in human milk and adipose tissues

J. Food Hyg. Soc. Japan

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Experientia

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Acta Pharmacol. Toxicol.

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Chem.-Biol. Interact.

Selective retention of 2,3,6-substituted 14C-pentachlorobiphenyls in the lung of mice

Gen. Pharmacol.

Identifizierung und Metabolisierbarkeit von Polychlorierten Biphenylen

Naturwissenschaften

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Drug Metab. Dispos.

The influence of molecular structure on the retention and excretion of polychlorinated biphenyls by the mouse

Toxicol. Appl. Pharmacol.

Synthesis of [14C]biphenyl and some chlorinated [14C]biphenyls containing 4-chloro-, 2,4-dichloro- and 2,3,6-trichlorophenyl nuclei from the corresponding labelled anilines

Chemosphere

Studies on the distribution and fate of S35-labelled benzyl-penicillin in the body

Acta Radiol.

Selective retention of 2,3,6-substituted ¹⁴C-pentachlorobiphenyls in the lung of mice

Synthesis of [¹⁴C]biphenyl and some chlorinated [¹⁴C]biphenyls containing 4-chloro-, 2,4-dichloro- and 2,3,6-trichlorophenyl nuclei from the corresponding labelled anilines

Studies on the distribution and fate of S³⁵-labelled benzyl-penicillin in the body