Short communicationThe cytochrome P-450 metabolite complex derived from troleandomycin: Properties in vitro and stability in vivo
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Cited by (29)
Drug Metabolism: Cytochrome P450
2022, Comprehensive PharmacologyRoles of cytochrome P450 enzymes in pharmacology and toxicology: Past, present, and future
2022, Advances in PharmacologyCitation Excerpt :A relevant example is troleandomycin (Pessayre et al., 1983). The rates of breakdown of the complex is slow and takes more than a day in vivo (Delaforge, Jaouen, & Mansuy, 1984). Generation of reactive metabolites that bind to P450 covalently to inhibit.
In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: A comparison with human liver microsomes
2008, Biochemical PharmacologyCitation Excerpt :By contrast, no statistically significant correlations (P > 0.05) were found between PNU-159682 formation rate and dextromethorphan-O-demethylase activity (Figs. 4–6). In order to confirm the above results, we examined the effects of the CYP3A inhibitors ketoconazole [15–17] and TAO [18–20] on the rate of PNU-159682 formation by microsomes obtained from males of the various animal species. For the purpose of comparison, the same experiments were also performed using pooled, mixed-gender HLMs.
Pharmacodynamic analysis of the electrocardiographic interaction between disopyramide and erythromycin in rats
1999, Journal of Pharmaceutical SciencesSolution conformation of methylated macrolide antibiotics roxithromycin and erythromycin using NMR and molecular modelling. Ribosome-bound conformation determined by TRNOE and formation of cytochrome P450-metabolite complex
1998, International Journal of Biological Macromolecules