Biotransformation, hepatopancreas DNA binding and pharmacokinetics of benzo[a]pyrene after oral and parenteral administration to the American lobster, Homarus americanus
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Multibiomarker interactions to diagnose and follow-up chronic exposure of a marine crustacean to Hazardous and Noxious Substances (HNS)
2018, Environmental PollutionCitation Excerpt :Nevertheless, cyanide can also induce brain toxicity and cause a failure in use of molecular oxygen in peripheral tissues, which can result in cellular hypoxia (CEPA, 2000). Under hypoxic conditions, organisms shift from aerobic to anaerobic metabolism of glucose, in which pyruvate is converted glucose molecules) stores, it is less effective, than IDH, leading to a decrease in net energy production from (James et al., 1995) moles to 2 mol of ATP per mole of glucose (Livingstone, 1998). Reduced capacity for ATP production, relying mainly in the anaerobic pathway, may put these marine crabs in disadvantage if under multiple stressors, such as predator escaping, obtaining food, detoxification and osmotic regulation.
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2013, Science of the Total EnvironmentCitation Excerpt :Compared to GC–MS the method also requires a considerably smaller amount of sample and allows a cost-effective determination of PAH compounds in individual organisms. Furthermore, in species that show slow elimination rates, PAH metabolites may represent a significant part of tissue burdens, e.g., as found for naphthalene and benzo[a]pyrene accumulation in muscle and the digestive gland of other decapod species (Laurén and Rice, 1985; James et al., 1995). In such situations, the assessment of the parent substance alone may lead to underestimated measurements, overlooking the risks posed by the potentially toxic metabolites produced from metabolism and biotransformation (Livingstone, 1998).
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Present address: Eppley Cancer Research Institute, University of Nebraska, Omaha, NE 68105, USA.
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