Multisubstrate flavin-containing monooxygenases: applications of mechanism to specificity
References (26)
- et al.
The liver microsomal FAD-containing monooxygenases. Spectral characterization and kinetic studies
J. Biol. Chem.
(1979) - et al.
Transient intermediates of the methane monooxygenase catalytic cycle
J. Biol. Chem.
(1993) - et al.
The reductive half-reaction of liver microsomal FAD-containing monooxygenases
J. Biol. Chem.
(1981) - et al.
The oxidative half-reaction of liver microsomal FAD-containing monooxygenase
J. Biol. Chem.
(1981) - et al.
Xenobiotic biotransformation in the Pacific oyster (Crassostrea gigas)
Comp. Biochem. Physiol.
(1989) - et al.
Trimethylamine oxidase of nurse shark liver and its relation to mammalian mixed-function amine oxidase
Comp. Biochem. Physiol.
(1973) - et al.
Flavin-containing monooxygenase activity in liver microsomes from the rainbow trout (Oncorhynchus mykiss)
Aquat. Toxicol.
(1991) - et al.
Microsomal oxidase IV. Properties of a mixed-function amine oxidase isolated from pig liver microsomes
Arch. Biochem. Biophys.
(1972) Flavin-containing monooxygenases: enzymes adapted for multisubstrate activity
Trends Pharmacol. Sci.
(1990)Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases
Annu. Rev. Pharmacol. Toxicol.
(1993)
The flavin-containing monooxygenase as a sulfur oxidase
The flavin-containing monooxygenase as an amine oxidase
The multisubstrate FAD-containing monooxygenase
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2020, International Journal of Biological MacromoleculesCytochrome P450 and flavin-containing monooxygenase enzymes are responsible for differential oxidation of the anti-thyroid-cancer drug vandetanib by human and rat hepatic microsomal systems
2020, Environmental Toxicology and PharmacologyCitation Excerpt :Vandetanib was oxidized to two metabolites that were separated by HPLC (Fig. 2a) and identified by mass spectrometry as N-desmethylvandetanib and vandetanib N-oxide (Fig. 2b). As we have shown previously (Indra et al., 2019), the formation of vandetanib metabolites in hepatic microsomes was dependent on NADPH which serves as cofactor for both POR-mediated CYP catalysis and FMO-mediated oxidative reactions (Gao et al., 2018; Guengerich, 2018; Itoh et al., 1993; Krueger and Williams, 2005; Poulsen and Ziegler, 1995; Ziegler, 2002). This demonstrated that CYPs and/or FMOs are responsible for the formation of these metabolites in the subcellular systems.
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