Regular articleInteraction of benzimidazole anthelmintics with Haemonchus contortus tubulin: Binding affinity and anthelmintic efficacy
References (32)
- et al.
Mebendazole concentrations in sheep plasma
Research in Veterinary Science
(1983) A rapid and sensitive method for quantitation of microgram quantities of protein utilising the principle of protein-dye binding
Analytical Biochemistry
(1976)Benzimidazoles: Veterinary uses
Parasitology Today
(1990)Use of benzimidazole chemotherapy in human helminthiases: Indications and efficacy
Parasitology Today
(1990)- et al.
A comparison of the interaction of anthelmintic benzimidazoles with tubulin isolated from mammalian tissue and the parasite nematode Ascaridia galli
Biochemical Pharmacology
(1984) - et al.
Interaction of anthelmintic benzimidazoles and benzimidazole derivatives with bovine brain tubulin
Biochimica et Biophysica Acta
(1978) - et al.
The metabolism of benzimidazole anthelmintics
Parasitology Today
(1990) - et al.
Morphological changes in trichostrongylid eggs after treatment with fenbendazole
Veterinary Parasitology
(1982) The role of the cytoskeletal protein tubulin in the mode of action and mechanism of drug resistance to benzimidazole carbamates
International Journal of Parasitology
(1988)- et al.
Comparison of inhibition of polymerisation of mammalian tubulin and helminth ovicidal activity by benzimidazole carbamates
Veterinary Parasitology
(1987)
Specific interaction of benzimidazole anthelmintics with tubulin: High affinity binding and benzimidazole resistance in Haemonchus contortus
Molecular and Biochemical Parasitology
Specific interaction of benzimidazole anthelmintics with tubulin: Comparison of developing stages of thiabendazole-susceptible and thiabendazole-resistant strains of Haemonchus contortus
Biochemical Pharmacology
Trichostrongylus colubriformis, in vitro culture of parasite stages and their use for evaluation of anthelmintics
Research in Veterinary Science
Neurotransmitter, hormone or drug receptor binding models
Possibilities and limitations in the detection of anthelmintic resistance
Ultrastructural changes in Ascaris suum intestine after mebendazole treatment in vivo
Journal of Parasitology
Cited by (123)
Pharmacologic interaction between oxfendazole and triclabendazole: In vitro biotransformation and systemic exposure in sheep
2019, Experimental ParasitologyCitation Excerpt :In the present study, only OFZ MRT was significantly altered (roughly 16% increased) upon coadministration. In spite of exhibiting lesser potency than the parent compound, attributed to a lower affinity for helminth tubulin (Lubega and Prichard, 1991), OFZ does show anthelmintic activity. For this reason, altered OFZ PK parameters associated with coadministration with TCBZ could affect clinical efficacy.
Strategies to Optimize the Efficacy of Anthelmintic Drugs in Ruminants
2018, Trends in ParasitologyOxidative transformation kinetics and pathways of albendazole from reactions with manganese dioxide
2018, Journal of Hazardous MaterialsCitation Excerpt :However, no further biological oxidized product (i.e. ABZ-SO2 with two oxygens added on the sulfur atom) was observed. ABZ-SO2 has been suggested to possess lower bio-toxicity than ABZ and ABZ-SO [13]. Unfortunately, MnO2 may not have enough oxidative power to further oxidize ABZ-SO.
Benzimidazole toxicosis in rabbits: 13 cases (2003 to 2011)
2014, Journal of Exotic Pet MedicineA pharmacology-based comparison of the activity of albendazole and flubendazole against Echinococcus granulosus metacestode in sheep
2013, Acta TropicaCitation Excerpt :In the case of ABZ, two metabolites are found in the systemic circulation after its administration to different animal species, ABZ-sulphoxide (ABZSO) and ABZ-sulphone (ABZSO2) (Marriner and Bogan, 1980; Prichard et al., 1985; Alvarez et al., 1995; Sánchez et al., 2000). While ABZSO is an active metabolite, ABZSO2 is not used as an anthelmintic and is probably inactive in vivo (Lubega and Prichard, 1999). However, most studies on ABZSO2 activity have been carried out in nematodes; its potential activity against other helminths, including cestodes and trematodes, is unknown.