Pharmacokinetics of 19-nortestosterone esters in normal men
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The scaffold protein RACK1 is a target of endocrine disrupting chemicals (EDCs) with important implication in immunity
2017, Toxicology and Applied PharmacologyCitation Excerpt :Results obtained confirm that AR agonist/antagonist can modulate RACK1 expression in opposite way, leading to an enhancement or a decrease in the response to classic innate immunity stimuli and modulation of cell proliferation. The concentrations used were relevant to human exposure, as for nandrolone following intramuscular injection of either 50 mg 19-nortestosterone-3-(p-hexoxyphenyl)-propionate or 50 mg 19-nortestosterone-decanoate, serum nandrolone increased rapidly to maximal concentrations of 4.6 ± 3.2 and 2.0 ± 1.3 nM (± SD), respectively (Belkien et al., 1985). While the levels of p,p′DDT and p,p′DDE in the human population are highly variable, in a study conducted in a relatively highly exposed population of farmers in the United States, the median plasma p,p′DDE concentration was 7.7 μg/l equivalent to 24 nM (range, 0.6–77.4 μg/l) (Cooper et al., 2004), while Barraza-Villarreal et al. (2004) reported in Mexican males mean plasma p,p′DDE and p,p′DDT levels of 203.5 μg/l equivalent to 640 nM and 67.4 μg/l equivalent to 21 nM, respectively.
Atypical excretion profile and GC/C/IRMS findings may last for nine months after a single dose of nandrolone decanoate
2016, SteroidsCitation Excerpt :Even though the 19-NT metabolites 19-NA and 19-NE were detected 9 months post dose, the excretion of 19-NT itself was not detectable on day 120 and 270 in any of the subjects. This is in agreement with other studies showing that the half-life of ND is approximately 8–12 days [22,23]. The reason for the longer half-life of the metabolites is not known, but may be due to accumulation in adipose tissues and/or more extensive binding to carrier proteins.
The beneficial effects of strength exercise on hippocampal cell proliferation and apoptotic signaling is impaired by anabolic androgenic steroids
2014, PsychoneuroendocrinologyCitation Excerpt :In general, AAS users are engaged in typical strength exercise to improve their muscle mass by hypertrophy (Hartgens and Kuipers, 2004). Yet, when administered chronically (13 weeks), the serum concentration of ND remains different from basal values until 18 weeks after the last injection (Belkien et al., 1985). In addition, pharmacokinetics studies have shown that the half-life of ND even after a single injection is approximately 5 ± 8 days (5–17 days) (Belkien et al., 1985; Minto et al., 1997; Bagchus et al., 2005).
On the association between nandrolone-mediated testosterone reduction during alcohol intoxication and attenuated voluntary alcohol intake in rats
2013, Pharmacology Biochemistry and BehaviorCitation Excerpt :The present testosterone elevations are puzzling since the primary effect of the nandrolone decanoate treatment should be a rather long-lasting feedback inhibition of the testosterone synthesis (Minto et al., 1997). This long-lasting testosterone reduction has been explained by the slow half-life of the release of the ester from the intramuscular depot, approximately 6–8 days in humans (Belkien et al., 1985; Wijnand et al., 1985) and 5 days in rats (van der Vies, 1985). In the present study, we have used subcutaneous nandrolone decanoate injection, which is not known to affect pharmacokinetics in a substantially different way compared with intramuscular administration.
Fullerene-C<inf>60</inf>-modified electrode as a sensitive voltammetric sensor for detection of nandrolone-An anabolic steroid used in doping
2007, Analytica Chimica ActaCitation Excerpt :The OSWV method was finally selected for the determination of nandrolone since it was able to determine lower concentrations of this substance. When released in the bloodstream, the ester bond of nandrolone decanoate is easily broken yielding the parent drug, nandrolone [3]. Buckminsterfullerene (C60) has attracted much attention of researchers owing to its remarkable electrochemical properties [24].