Carcinogenicity of catechol estrogens in Syrian hamsters
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2019, Molecular and Cellular EndocrinologyCitation Excerpt :With both endogenous estrogens and CEEs, the 4-hydroxylation pathway is predominately catalyzed by P4501B1/1A1 (Sissung et al., 2006; Spink et al., 2001). While 2-hydroxylation of endogenous estrogens is regarded as a benign metabolic pathway, 4-hydroxylation leads to cytotoxic and carcinogenic metabolites (Li and Li, 1987; Liehr et al., 1986; Newbold and Liehr, 2000). These electrophilic/redox-active quinones can cause damage within cells by alkylation and/or oxidation of cellular proteins and DNA in many tissues.
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