Elsevier

Life Sciences

Volume 15, Issue 12, 15 December 1974, Pages 2189-2195
Life Sciences

Norcocaine: A pharmacologically active metabolite of cocaine found in brain

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Abstract

N-Demethylation of cocaine results in the production of norcocaine, which has been identified by gas chromatography-mass spectrometry in the brains of monkeys given repeated doses of cocaine. This metabolite is about as active as cocaine in inhibiting uptake of 3H-norepinephrine by synaptosomes prepared from rat brain. Other cocaine derivatives have been found to be relatively inactive in inhibiting uptake of this amine.

References (11)

  • N.N. Valanju et al.

    J. Chromatogr.

    (1973)
  • H. Langeker et al.

    Arch. Exp. Pathol. Pharmakol.

    (1938)
  • L.A. Woods et al.

    J. Pharmacol. Exp. Ther.

    (1951)
  • F. Montesinos

    Bull. Narcotics

    (1965)
  • R.V. Ortiz

    An. Fac. Quim.

    (1966)
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