Elsevier

Life Sciences

Volume 21, Issue 12, 15 December 1977, Pages 1813-1819
Life Sciences

Urinary excretion of a quaternary ammonium glucuronide metabolite of cyproheptadine in humans undergoing chronic drug therapy

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Abstract

The urinary excretion of cyproheptadine glucuronide was studied during the first and third weeks of drug treatment in women undergoing chronic therapy for anorexia nervosa. An average of 24% of the daily cyproheptadine dose was excreted at a relatively constant rate as the quaternary ammonium glucuronide metabolite. No remarkable changes in the rate or extent of the urinary excretion of cyproheptadine glucuronide were found with continued drug treatment. The results indicate that formation of a quaternary ammonium glucuronide represents a quantitatively important pathway for elimination of cyproheptadine in humans.

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