Elsevier

Life Sciences

Volume 39, Issue 4, 28 July 1986, Pages 297-301
Life Sciences

Pharmacological effects of oral saikosaponin a may differ depending on conditions of the gastrointestinal tract

https://doi.org/10.1016/0024-3205(86)90647-8Get rights and content

Abstract

Saikosaponin a and its 8 derivatives, structural isomers and their monoglycosides and aglycones, which were formed in the gastrointestinal tract with their fecal contents depending on food intake, showed different effects on protein synthesis by rat hepatocytes in primary culture. Saikosaponin a and its monoglycoside and aglycone were detectable in plasma of rats when saikosaponin a was orally administered. Pharmacological effects of saikosaponin a when orally administered may differ depending on conditions of the gastrointestinal tract.

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