Time course of ethanol-induced changes in serotonin metabolism
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Cited by (67)
Determination of serotonin metabolites in urine sample by liquid chromatography–mass spectrometry as biomarkers of recent alcohol intake: Implication for aircraft accident investigation
2021, Medical Journal Armed Forces IndiaCitation Excerpt :This established procedure when used in the actual scenario of aircraft accident, where there are high chances of microbial formation of ethanol after death, can adequately differentiate ethanol produced from microbial fermentation from ethanol ingested by the pilot before crash. This is therefore a very useful tool in aircraft accident investigation.10 There are no established enzymatic or ELISA platforms to estimate the ratio of 5-HT metabolites.
Behavioral outcomes of monoamine oxidase deficiency: Preclinical and clinical evidence
2011, International Review of NeurobiologyCitation Excerpt :Small amounts of 5-HT (1–5%) are converted into 5-hydroxyindolethanol (5-HIET, also termed 5-hydroxytryptophol) by either ALR or ADH (Feldstein and Williamson, 1968; Beck et al., 1984; Consalvi et al., 1986; Svensson et al., 1999) (Table I). Interestingly, the amount of 5-HIET can be enhanced by compounds that compete with endogenous 5-HT metabolite for ALDH, such as ethanol (Helander et al., 1993). The metabolism of catecholamines (DA, NE, E) is served by both MAO (in conjunction with either ALDH or ALR) and catecholamine-O-methyl-transferase (COMT).
The Degradation of Serotonin: Role of MAO
2010, Handbook of Behavioral NeuroscienceCitation Excerpt :Small amounts of 5-HIAL have been shown to be converted into 5-hydroxytryptophol (5-HTOL) by either an NADH-dependent aldehyde reductase (ALR) or an NADPH-dependent alcohol-dehydrogenase (ADH) (Feldstein and Williamson, 1968; Consalvi et al., 1986; Svensson et al., 1999) (Figure 1). While the physiological brain concentration of 5-HTOL is only 1–5% of the 5-HIAA levels (Beck et al., 1984), intake of ethanol has been shown to produce a dramatic increase of 5-HTOL production (Helander et al., 1993), probably as a result of competitive inhibition of ALDH, as well as an increased NADH/NAD ratio, which enhances ADH activity (Davis et al., 1967; Lahti and Majchrowicz, 1974; Beck et al., 1982). Interestingly, this observation has led some authors to propose 5-HTOL/5-HIAA ratio as a sensitive marker of recent alcohol drinking (Voltaire et al., 1992; Helander et al., 1996).
Objective post-mortem diagnosis of chronic alcohol abuse - A review of studies on new markers
2008, Legal MedicineCitation Excerpt :Usually, the ratio of 5-HTOL to the major serotonin metabolite, 5-hydroxyindole-3-acetic acid (5-HIAA), is determined, thus compensating for urine dilution and dietary intake of serotonin. The ratio of metabolites remains elevated for several hours after ethanol is no longer detectable [34–36]. Similarly to EtG, the 5-HTOL/5-HIAA ratio provides a useful method for autopsy cases to demonstrate recent alcohol consumption but EtG is a superior marker of recent ethanol ingestion because it is a direct ethanol metabolite [35].
Chapter 17 Analytical markers of acute and chronic alcohol consumption
2008, Handbook of Analytical SeparationsA study of ethyl glucuronide in post-mortem blood as a marker of ante-mortem ingestion of alcohol
2007, Forensic Science International