Absorption, metabolism, and excretion of thiabendazole in man and laboratory animals
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Cited by (59)
Urban pathways of biocides towards surface waters during dry and wet weathers: Assessment at the Paris conurbation scale
2021, Journal of Hazardous MaterialsCitation Excerpt :First, the parent compound might be transformed back through the WWTP from metabolites or other compounds (Köck-Schulmeyer et al., 2013). Indeed, conjugated metabolites were identified for terbutryn (glutathione conjugated (Jeon et al., 2013)), thiabendazole (glucuronide and sulfate ester of 5-hydroxythiabendazole (Tocco et al., 1966)), and tebuconazole (TEB−OH and TEB−COOH, both as free molecules and as glucuronide conjugates (Mercadante et al., 2014)), which hence supports the first hypothesis for these three substances. For diuron, more investigations are needed to explain the negative removal.
The fungicide thiabendazole causes apoptosis in rat hepatocytes
2016, Toxicology in VitroCitation Excerpt :However, exposure to thiabendazole at higher concentrations exceeding 1000 μM for 10 h caused LDH release in rat hepatocytes, whereas LDH release was not detected at 500 μM (Sugihara et al., 1997). The micromolar concentrations of thiabendazole used in all of these studies are higher than the peak plasma concentrations (13 to 18 μg/ml) detected in humans (Tocco et al., 1966; EMA, 2004). However, hepatocytes were exposed to the drug for relatively short times (24 to 72 h) in these in vitro studies, whereas animals and humans are exposed to lower doses of thiabendazole for prolonged periods of time through diet and environment.
Determination of 5-hydroxythiabendazole in human urine as a biomarker of exposure to thiabendazole using LC/MS/MS
2014, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :The solubility of TBZ may be the dependent factor. Moreover, metabolites not found by the analytical method are likely to be formed; since the benzene ring in TBZ can undergo ring cleavage and, sulfoxidation has also been suggested [12]. Before the experimental exposure, the 5-OH-TBZ levels in urine were below LOD in both volunteers.
Myeloperoxidase-mediated bioactivation of 5-hydroxythiabendazole: A possible mechanism of thiabendazole toxicity
2011, Toxicology in VitroCitation Excerpt :Additionally, TBZ is used as an agricultural antifungal and food preservative (Walton et al., 1999). Radiometric assays in humans, conducted by Tocco et al. (1966), have shown that oral dosage of TBZ yields a peak plasma level after 2 h. After 24 h, 85% of the radio-labeled drug has been excreted in urine (61%) or feces (24%).
Effect of thiabendazole on some rat hepatic xenobiotic metabolising enzymes
2004, Food and Chemical Toxicology