The role of metabolism in chloroform hepatotoxicity
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Beyond Ether and Chloroform—A Major Breakthrough With Halothane
2017, Journal of Anesthesia HistoryCitation Excerpt :Generations of patients had experienced the nausea and vomiting that affected almost everyone who received ether anesthesia.11–13 Chloroform, introduced with ether almost a century earlier, was associated with significant cardiac and hepatic toxicity.14–16 We discuss the introduction, generalized acceptance, and steady decline in the use of halothane—the first inhalation anesthetic introduced in the 20th century.
Effects of singly administered betaine on hepatotoxicity of chloroform in mice
1998, Food and Chemical ToxicologyDichloroacetic acid treatment increases hepatic CYP2E1 in male and female rats
1996, Toxicology and Applied PharmacologyRisk extrapolation for chlorinated methanes as promoters vs initiators of multistage carcinogenesis
1990, Fundamental and Applied ToxicologyChanges in cytochrome P450 molecular species in rat liver in chloroform intoxication
1986, Biochemical Pharmacology
Copyright © 1974 Published by Elsevier Inc.