Effect of alteration of rat hepatic mixed-function oxidase (MFO) activity on the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
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Dioxin-induced retardation of development through a reduction in the expression of pituitary hormones and possible involvement of an aryl hydrocarbon receptor in this defect: A comparative study using two strains of mice with different sensitivities to dioxin
2014, Toxicology and Applied PharmacologyCitation Excerpt :The accumulation of TCDD in tissues during the perinatal stages is greater in females than in males (Li et al., 1995), and this may be due to a difference in the formation of a complex of TCDD and α-fetoprotein, a fetus-specific carrier protein (Sotnichenko et al., 1999). In agreement with these pieces of evidence, some previous studies have demonstrated that females are more sensitive to TCDD than males (Beatty et al., 1978; Myllymäki et al., 2005). Such sex differences may underlie the different sensitivity to TCDD between genders in terms of gonadotropin formation.
Unexpected gender difference in sensitivity to the acute toxicity of dioxin in mice
2012, Toxicology and Applied PharmacologyCitation Excerpt :The risk assessment of dioxins is challenging due to the strong dependence of their biological responses on such factors as species, strain, age, and tissue (Pohjanvirta and Tuomisto, 1994). In rats, it has been established that gender also plays an important role, with female rats being about twice as sensitive to the acute lethality of TCDD as males (Beatty et al., 1978; Pohjanvirta et al., 1993). To date, this aspect has not been addressed in mice, in which acute toxicity studies have only employed male animals (Birnbaum et al., 1990; Chapman and Schiller, 1985; Jones and Greig, 1975; McConnell et al., 1978; Vos et al., 1974; Weber et al., 1995).
Transgenic mouse lines expressing rat AH receptor variants - A new animal model for research on AH receptor function and dioxin toxicity mechanisms
2009, Toxicology and Applied PharmacologyAromatic hydrocarbon receptor expression and function in liver of hypophysectomized male rats
2002, Toxicology and Applied PharmacologyThe AH receptor of the most dioxin-sensitive species, guinea pig, is highly homologous to the human AH receptor
2001, Biochemical and Biophysical Research Communications