Deuterium isotope effect on the metabolism and toxicity of 1,2-dibromoethane
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2017, Methods in EnzymologyCitation Excerpt :However, its genotoxicity is related to another pathway, glutathione conjugation (Guengerich, 2005). Deuteration of ethylene dibromide blocks oxidation and increases the genotoxicity in rats (White, Gandolfi, Bowden, & Sipes, 1983), as does administration of the P450 2E1/2A6 inhibitor disulfiram (Wong, Winston, Hong, & Plotnick, 1982). The first application of KIEs to P450 drug metabolism was that of Elison et al. (1961) on the N-demethylation of morphine, which is recognized today as a cytochrome P450 reaction.
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