The role of p-aminophenol in acetaminophen-induced nephrotoxicity: Effect of bis(p-nitrophenyl) phosphate on acetaminophen and p-aminophenol nephrotoxicity and metabolism in Fischer 344 rats☆
References (28)
- et al.
The nephrotoxicity of p-aminophenol. II. The effect of metabolic inhibitors and inducers
Chem. Biol. Interact.
(1979) - et al.
The nephrotoxicity of p-aminophenol. I. The effect of microsomal cytochromes, glutathione, and covalent binding in kidney and liver
Chem. Biol. Interact.
(1979) - et al.
Inhibition of phenacetin- and acetanilide-induced methemoglobinemia in the rat by the carboxylesterase inhibitor bis-(p-nitrophenyl) phosphate
Biochem. Pharmacol.
(1969) - et al.
Use of isolated kidney cells for study of drug metabolism
Biochem. Pharmacol.
(1979) - et al.
Protein measurement with Folin phenol reagent
J. Biol. Chem.
(1951) - et al.
Renal necrosis, glutathione depletion, and covalent binding after acetaminophen
Toxicol. Appl. Pharmacol.
(1978) - et al.
Molecular basis for several drug-induced nephropathies
Amer. J. Med.
(1977) - et al.
Nephrotoxicity of p-aminophenol, a metabolite of acetaminophen, in the Fischer 344 rat
Toxicol. Appl. Pharmacol.
(1982) - et al.
Acetaminophen nephrotoxicity in the rat. I. Strain differences in nephrotoxicity and metabolism
Toxicol. Appl. Pharmacol.
(1983) - et al.
Acetaminophen nephrotoxicity in the rat. II. Strain differences in the nephrotoxicity and metabolism of p-aminophenol, a metabolite of acetaminophen
Toxicol. Appl. Pharmacol.
(1983)
Acetaminophen nephrotoxicity in the rat: Renal metabolic activation in vitro
Toxicol. Appl. Pharmacol.
Acetaminophen nephrotoxicity in the rat: Quantitation of renal metabolic activation in vivo
Tox. Appl. Pharmacol.
Acetaminophen nephrotoxicity: Studies on renal acetylation and deacetylation
J. Pharmacol. Exp. Ther.
Renal tubular transport: Accumulation of p-aminohippurate by rabbit kidney slices
Amer. J. Physiol.
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2012, Journal of Photochemistry and Photobiology A: ChemistryCitation Excerpt :Also, AA shows toxicity to hepatocyte on account of the generation of N-acetyl-p-benzoquinonimine by cytochrome P450 and covalent binding to some proteins [12], but AA had no effects on the aquatic organisms. PA is 5 to 10 times more potent than AA as a nephrotoxicant in F344 rats [24], and the inhibition of AA deacetylation by preventing the formation of PA greatly reduced renal toxicity suggesting that renal toxicity of AA is due to PA at least in part [25]. From these reports, it is tempting to speculate that compound 1 has a same mechanism on account of the similarity of chemical structure to PA.
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Portions of this study have been presented previously (Toxicologist 1983, 3, 113).
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Supported by a Monsanto Predoctoral Fellowship in toxicology.
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Present address: Smith Kline & French Laboratories, 1500 Spring Garden St., P.O. Box 7929, Philadelphia, Pa. 19101.