[15] Reversible enzyme inhibition
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2000, Journal of Biological ChemistryCitation Excerpt :All enzymes were dissolved in saline/0.1% (w/v) bovine serum albumin, except bovine pancreatic PLA2 and hsPLA2-II, which were dissolved in 20 mm Tris, pH 8.0, and 1 m NaCl, 10 mm Tris, pH 7.5, respectively. The IC50 was determined by preincubating varying concentrations of NAI (10.5 mg/mL) in a constant volume, against a constant amount of enzyme (see above and Refs. 49-51). The concentration of NAI was varied between 30 μm and 70 pm (PLA2- and assay-dependent) until a sigmoidal dose response curve was generated allowing calculation of the IC50 value.
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