Cannabielsoin as a new metabolite of cannabidiol in mammals
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2016, Frontiers in NeuroendocrinologyCitation Excerpt :The converse is true for rats, in which the activity of the microsomal alcohol oxygenase is ∼3× higher in males than in females (Matsunaga et al., 2000). Finally, CBD is converted by guinea pig liver microsomes to 7-OH, 6-OH and 4-OH variants (Yamamoto et al., 1991). CBD also undergoes hepatic conversion to cannabielsoin in several rodent species, and the male rat microsomal production of this metabolite is over twice the rate as that observed in females (Yamamoto et al., 1991).
Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells
2015, Life SciencesCitation Excerpt :There are a lot of mutagenic and procarcinogenic compounds, such as B[a]P, in marijuana tar [9,10]. For phytocannabinoids contained in marijuana tar, on the other hand, the mutagenicity and carcinogenicity of Δ9-THC, 1α,2α-epoxyhexahydrocannabinol, and 1S,2R-epoxy-CBD-2′,6′-diacetate have been shown to be negative [37–42]. However, the majority of phytocannabinoids including CBD have not yet been characterized as mutagen/carcinogen or non-mutagen/non-carcinogen.