The cellular pharmacology of methotrexate

https://doi.org/10.1016/0163-7258(85)90083-XGet rights and content

First page preview

First page preview
Click to open first page preview

References (117)

  • I.D. Goldman et al.

    Carrier-mediated transport of the folic acid analogue, methotrexate, in the L1210 leukemia cell

    J. biol. Chem.

    (1968)
  • M.T. Hakala et al.

    Relation of folic acid reductase to amethopterin resistance in cultured mammalian cells

    J. biol. Chem.

    (1961)
  • G.B. Henderson et al.

    Transport of methotrexate in L1210 cells: effect of ions on the rate and extent of uptake

    Archs Biochem. Biophys.

    (1980)
  • G.B. Henderson et al.

    Intracellular phosphate and its possible role as an exchange anion for active transport of methotrexate in L1210 cells

    Biochem. biophys. Res. Commun.

    (1982)
  • B.T. Hill et al.

    DDMP [2,4-diamino-5-(3′,4′-dichlorophenyl)mthylpyrimidine]

    Cancer Treat. Rev.

    (1980)
  • B.T. Hill et al.

    Methotrexate resistance and uptake o9f DDMP by L5178Y cells

    Eur. J. Cancer

    (1975)
  • R.C. Jackson et al.

    Studies with a mathematical model of folate metabolism

    Archs Biochem. Biophys.

    (1973)
  • R.C. Jackson et al.

    Acquired methotrexate resistance in lymphoblasts resulting from altered kinetic properties of dihydrofolate reductase

    Eur. J. Cancer

    (1977)
  • R.C. Jackson et al.

    Reactivation of dihydrofolate reductase inhibited by methotrexate or aminopterin

    Archs Biochem. Biophys.

    (1977)
  • R.C. Jackson et al.

    Biochemical pharmacology of the lipophilic antifolate, trimetrexate

    Adv. Enzyme Reg.

    (1984)
  • J. Lankelma et al.

    The role of 7-hydroxymethotrexate during methotrexate anticancer chemotherapy

    Cancer Lett.

    (1980)
  • N.S. Lichtenstein et al.

    Characteristics of folic acid transport in the L1210 leukemia cell

    Biochim. biophys. Acta

    (1969)
  • R.G. Moran et al.

    Folate metabolism in mammalian cells in culture: 1. Partial characterization of the folate derivatives present in L1210 mouse leukemia cells

    J. biol. Chem.

    (1976)
  • Z. Nimec et al.

    Regulatory aspects of the glutamylation of methotrexate in cultured hepatoma cells

    Archs. Biochem. Biophys.

    (1983)
  • A. Rosowsky et al.

    Effects of methotrexate esters and other lipophilic antifolates on methotrexate-resistant human leukemic lymphoblasts

    Biochem. Pharmac.

    (1980)
  • F.M. Sirotnak et al.

    Stereospecificity at carbon 6 at formyltetrahydrofolate as a competitive inhibitor of transport and cytotoxicity of methotrexate in vitro

    Biochem. Pharmac.

    (1979)
  • C.J. Allegra et al.

    Inhibition of the folate-dependent enzymes of denovo purine synthesis and folate interconverting enzymes by methotrexate polyglutamates

  • J.E. Baggot

    Inhibition of purified avian liver aminoimidazolecarboxamide ribotide transformylase by polyglutamates of methotrexate and oxidized folates

  • R.A. Bender

    Membrane transport of methotrexate (NSC-740) in human neoplastic cells

    Cancer Chemother. Rep.

    (1975)
  • J.R. Bertino et al.

    New approaches to chemotherapy with folate antagonists: use of leucovorin ‘rescue’ and enzymic folate depletion

    Ann. N.Y. Acad. Sci.

    (1971)
  • J.A. Besserer et al.

    Studies on cellular resistance and membrane transport with the quinazoline antifolate, trimetrexate

  • W.F. Bobzien et al.

    The mechanism of folate transport in rabbit reticulocytes

    J. clin. Invest.

    (1972)
  • J. Borsa et al.

    Studies relating to the mode of action of methotrexate. II. Studies on sites of action in L-cells in vitro

    Molec. Pharmac.

    (1969)
  • D. Bowen et al.

    A basis for fluoropyrimidine-induced antagonism to methotrexate in Ehrlich ascites tumor cells in vitro

    Cancer Res.

    (1978)
  • H. Breithaupt et al.

    Pharmacokinetics of methotrexate and 7-hydroxymethotrexate following infusions of high-dose methotrexate

    Cancer Treat. Rep.

    (1982)
  • P.L. Chello et al.

    Schedule-dependent synergism of methotrexate and vincristine against L1210 leukemia

    Cancer Treat. Rep.

    (1979)
  • M. Dembo et al.

    Effects of metabolic deprivation on methotrexate transport in L1210 leukemia cells: further evidence for separate influx and efflux systems with different energetic requirements

    J. Memb. Biol.

    (1984)
  • H. Diddens et al.

    Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate

    Cancer Res.

    (1983)
  • I. Djerassi

    High dose methotrexate and citrovorum factor rescue: background and rationale

    Cancer Chemother. Rep.

    (1975)
  • G. Fabre et al.

    In vitro formation of polyglutamyl derivatives of methotrexate and 7-hydroxymethotrexate in human lymphoblastic leukemia cells

    Cancer Res.

    (1983)
  • G. Fabre et al.

    Interactions between 7-hydroxymethotrexate and methotrexate at the cellular level in the Ehrlich tumor in vitro

    Cancer Res.

    (1984)
  • I. Fabre et al.

    Selectivity of glycine, adenosine and thymidine protection of granulocytic progenitor cells versus tumor cells against methotrexate cytotoxicity in vitro: correlation with the formation of methotrexate polyglutamate derivatives

    Cancer Res.

    (1984)
  • G.A. Fischer

    Increased levels of folic acid reductase to amethopterin in leukemic cells

    Biochem. Pharmac.

    (1961)
  • W.F. Flintoff et al.

    Methotrexate-resistant chinese hamster ovary cells contain a dihydrofolate reductase with an altered affinity for methotrexate

    Biochemistry

    (1980)
  • E. Frei et al.

    New approaches to cancer chemotherapy with methotrexate

    New Engl. J. Med.

    (1975)
  • D.W. Fry et al.

    Further studies on the charge related alterations of methotrexate transport in Ehrlich ascites tumor cells by ionic liposomes: correlation with liposome-cell association

    J. Memb. Biol.

    (1982)
  • D.W. Fry et al.

    Alteration of carrier-mediated transport of methotrexate in Ehrlich ascites tumor cells by charged liposomes

    J. Memb. Biol.

    (1979)
  • D.W. Fry et al.

    Effects of 2,4-dinitrophenol and other metabolic inhibitors on the bidirectional fluxes, net transport, and intracellular binding of methotrexate in Ehrlich ascites tumor cells

    Cancer Res.

    (1980)
  • D.W. Fry et al.

    Augmentation of the intracellular levels of polyglutamyl derivatives of methotrexate by vincristine and probenecid in Ehrlich ascites tumor cells

    Cancer Res.

    (1982)
  • D.W. Fry et al.

    Analysis of the role of membrane transport and polyglutamylation of methotrexate in gut and the Ehrlich tumor in vivo as factors in drug sensitivity and selectivity

    Cancer Res.

    (1983)
  • Cited by (221)

    • Conventional treatment and new drugs

      2023, Natural Plant Products in Inflammatory Bowel Diseases: Preventive and Therapeutic Potential
    View all citing articles on Scopus
    View full text