Current progress on nucleoside antibiotics
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Design, synthesis and conformation-activity relationship analysis of LNA/BNA-type 5′-O-aminoribosyluridine as MraY inhibitors
2022, Bioorganic and Medicinal ChemistryCitation Excerpt :There also exist a class of natural products possessing a nucleoside moiety as a key structure, and they include a variety of structural modifications of nucleosides. Reflecting the inherent manifold roles of nucleosides, biological activities of these nucleoside natural products are wide ranging.1–8 Generally, it is important to understand and control the conformation of a ligand when it interacts with a target protein, which is known as a biologically active conformation.
The isolation of water-soluble natural products - challenges, strategies and perspectives
2021, Natural Product ReportsIdentification and characterization of enzymes involved in the biosynthesis of pyrimidine nucleoside antibiotics
2021, Natural Product ReportsStereoselective synthesis of aryl 1,2-cis-furanosides and its application to the synthesis of the carbohydrate portion of antibiotic hygromycin A
2017, Tetrahedron LettersCitation Excerpt :As depicted in Scheme 3, upon activation by Tf2O/Ph2SO at −68 °C in CH2Cl2 for 2 h,14 the d-arabinofuranose donor 1a was condensed with the phenol derivative 5 to give solely the β-monosaccharide glycoside 6 in 78% yield. The β-configuration of the newly formed arabinofuranosidic bond was clearly determined by the doublet for the anomeric signal of the Araf unit (δH1 = 5.633 ppm, d, JH1/H2 = 4.8 Hz).11 Removal of the 5-O-Quin group of 6 by treatment with sodium methoxide in methanol followed by Swern oxidation of the resulting alcohol afforded the corresponding aldehyde 7 in 70% yield over the two steps.
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Present address: Department of Marine Science, School of Marine Science and Technology, Tokai University, 3-2-1 Orido, Shimizu, Shizuoka 424, Japan.